In situ plasmonic monitoring of molecular dynamics using nanoscale probes = 나노수준 탐침을 이용한 분자 동역학의 실시간 플라즈몬 관찰 연구

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 35
  • Download : 0
For the past couple of decades, plasmonic nanoparticles such as Au and Ag have employed for wide applications as sensors and probes due to their unique optical properties originated from localized surface plasmon resonance (LSPR). We mainly utilize enhanced scattering light in the visible region. This resonant scattering light is highly sensitive to the surrounding environment; therefore, it can detect minute changes on the surface of nanoparticles. In addition, it provides high optical stability, which gives a great advantage as an imaging probe. Here, we used such enhanced scattering phenomenon of the plasmonic nanoparticles to monitor chemical reactions and biological processes at the nanometer level in real time. In chapter I, background knowledges and recent studies related to LSPR are introduced. In chapter II, the experimental in-situ observations during nanoscale reactions, including (1) Galvanic replacement reaction depending on the temperature and (2) sulfidation by cysteine, using Ag nanocubes as an ideal probe template are demonstrated. Introduction of the flow cell set-up and reaction temperature control allow us to monitor the nanoscale chemical reactions in an environment similar to the actual reaction conditions. In chapter III, we investigated the rotational movement of membrane protein (epidermal growth factor receptor, EGFR) in living cells using a nano-dimer structure assembled with oligonucleotides. This study enables visualization of protein rotation and conformational change, and furthermore provides insights into the activation mechanism.
Advisors
Song, Hyunjoonresearcher송현준researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[xvi, 110 p. :]

Keywords

localized surface plasmon resonance; nanoparticle; in situ monitoring; optical microscopy; molecular dynamics; 국소표면 플라즈몬 공명; 나노입자; 실시간 관찰; 광학현미경; 분자 동역학

URI
http://hdl.handle.net/10203/265465
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842459&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0