(The) roles and regulatory mechanisms of hepatic macrophages and hepatic eosinophils in alcoholic and non-alcoholic fatty liver disease = 알코올성 및 비알코올성 지방간질환에서 간 대식세포와 간 호산구의 역할 및 조절기전

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Hepatic macrophages play an important role not only in maintaining normal liver function, but also in the pathogenesis of liver disease. Therefore, many researches have been conducted on the mechanism of hepatic macrophage regulation and the treatment of liver diseases using it. In obesity and metabolic diseases, eosinophils have been reported to play an important role in maintaining homeostasis of metabolic function by controlling macrophages in adipose tissue. However, the mechanism by which eosinophils regulate hepatic macrophages in non-alcoholic fatty liver disease has not been well studied. In Part Ⅰ of this study, I confirmed that hepatic eosinophils inhibit non-alcoholic fatty liver disease by modulating the inflammatory function of hepatic monocytes. In addition, I found that fat-accumulated hepatocytes secrete microvesicles enriched with phosphatidylserine. I investigated the mechanism that hepatic eosinophils produced and secrete interleukin-4 by signal transduction by phosphatidylserine of microvesicles. Hepatic macrophages also play an important role in the pathogenesis of alcoholic fatty liver disease. In Part Ⅱ of this study, I found that hepatic monocytes differentiate into hepatic macrophages and studied the mechanism that the differentiation is mediated by $CX_3CR1$ signaling. In addition, $CX_3CR1$ signaling promoted the inflammatory function of differentiated hepatic macrophages, thereby exacerbating alcoholic fatty liver disease.
Advisors
Jeong, Won Ilresearcher정원일researcher
Description
한국과학기술원 :의과학대학원,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 의과학대학원, 2019.2,[v, 67 p. :]

Keywords

Alcoholic fatty liver disease▼aNon-alcoholic fatty liver disease▼aMonocyte▼aMacrophage▼aEosinophil▼aInterleukin-4▼aMicrovesicle▼aPhosphatidylserine▼aCD300f▼a$CX_3CR1$; 알코올성 지방간질환▼a비알코올성 지방간질환▼a단핵구▼a대식세포▼a호산구▼a인터루킨-4▼a미세소포▼a포스파티딜세린

URI
http://hdl.handle.net/10203/265103
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842493&flag=dissertation
Appears in Collection
MSE-Theses_Ph.D.(박사논문)
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