(The) role of intestinal microbiota in the maintenance of lacteal integrity = 장내 미생물총이 암죽관의 무결성 유지에 미치는 영향

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A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here I explored whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggered lacteal regression during adulthood, and delayed lacteal maturation during the postnatal period. In accordance with the functional compromise in lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipid into lacteals, was significantly diminished in lacteals of germ-depleted mice. Lacteal defect was also found in germ-free mice, but conventionalization of germ-free mice lead to normalization of lacteals in the villi. Mechanistically, VEGF-C secreted from villi macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, I conclude that gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villi macrophages in small intestine.
Advisors
Koh, Gou Youngresearcher고규영researcher
Description
한국과학기술원 :의과학대학원,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 의과학대학원, 2019.2,[iv, 71 p. :]

Keywords

Intestinal lymphatic vasculature▼alacteal▼amacrophage▼amicrobiota▼aVEGF-C; 소장 림프관▼a암죽관▼a대식세포▼a미생물총▼aVEGF-C

URI
http://hdl.handle.net/10203/265074
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842191&flag=dissertation
Appears in Collection
MSE-Theses_Ph.D.(박사논문)
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