Systems metabolic engineering for the production of C4 chemicals = 다양한 C4 화합물들의 생산을 위한 시스템 대사공학적 연구

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C4 chemicals are very important for every-life. Among them, succinic acid derivative products such as 1,4-butanediol, gamma-butyrolactone, and N-methylpyrrolidone. Currently, it is synthesized from the crude-oil. But the amount of crude oil is limited, and it causes the environmental problem. In order to overcome this problem, sustainable and eco-friendly process is required. One of them is biological process using bacteria. Bacteria could produce chemicals generally such as lactic acid, succinic acid and etc with mild condition, suitable media and carbon source. Metabolic engineering is the optimizing and regulatory processes within cell to increase the cells’ production of a certain substance. Using metabolic engineering, desired products could be produced easily. In order to produce various C4 chemicals, metabolic engineering was performed. Chapter 1 is an overview of the C4 world market size, utilization and explanation the chemical method for the synthesis of C4 chemicals. Chapter 2 reports the increasing succinic acid production in Mannheimia succiniciproducens. Chapter 3 reports the metabolic engineering for the production of malic and fumaric acids in Mannheimia succiniciproducens. Chapter 4 reports the production of 4-hydroxybutyric acid by introduction of 4-hydroxybutyric acid synthesis pathway production using high succinic acid producer and chemical conversion of 4-hydroxybutyric acid to gamma-butyrolactone which is a useful C4 chemical. Chapter 5 reports the production of 4-hydroxybutyric acid under micro-aerobic condition using Escherichia coli. Chapter 6 reports systems metabolic engineering for production of 4-hydroxybutyric acid in micro-aerobic conditition.
Advisors
Lee, Sang Yupresearcher이상엽researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2013
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2013.8,[xiv, 124 p. :]

Keywords

Metabolic engineering▼asuccinic acid▼amalic acid▼a4-hydroxybutyric acid; 대사공학▼a숙신산▼a말산▼a4-하이드록시부티릭산

URI
http://hdl.handle.net/10203/264877
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=848971&flag=dissertation
Appears in Collection
CBE-Theses_Ph.D.(박사논문)
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