Development of microneedle formulation for vaccine and protein application into skin = 피부 내 백신 및 단백질 전달을 위한 마이크로니들용 제형 연구

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The microneedle is delivery device suitable for intradermal drug delivery and can deliver a variety of drugs and vaccines. In this study, we have studied vaccine and protein delivery for microneedle as the main themes. First, various adjuvants were investigated to improve the immunogenicity of the vaccine delivered by the microneedle. Secondly, we investigated suitable viscosity enhancers and stabilizers in order to coat botulinum toxin on PLLA microneedle. In addition, we conducted a study to confirm whether the microneedle was suitable for the ferret, a representative model of influenza research.
Advisors
Kim, Yeuchunresearcher김유천researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2018.2,[v, 94 p. :]

Keywords

Microneedle▼avaccine▼aadjuvant▼aformulation▼astability; 마이크로니들▼a백신▼a애쥬번트▼a포뮬레이션▼a안정성

URI
http://hdl.handle.net/10203/264853
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=867897&flag=dissertation
Appears in Collection
CBE-Theses_Ph.D.(박사논문)
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