Elucidating the value processing mechanism in hippocampus = 해마체에서의 보상에 대한 가치 처리 메커니즘 규명

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It is generally believed that the hippocampus plays a crucial role in declarative memory—remembering facts and events—but not in gradual stimulus-response association or incremental value learning. Based on the finding that CA1 conveys strong value signals during dynamic foraging, we investigated the possibility that the hippocampus contributes to incremental value learning. Specifically, we examined effects of inactivating different subregions of the dorsal hippocampus on behavioral performance of mice performing a dynamic foraging task in a modified T-maze. A reinforcement learning model-based analysis indicated that inactivation of CA1, but not dentate gyrus, CA3, or CA2, impaired trial-by-trial updating of chosen value without affecting value-dependent action selection. As a result, it took longer for CA1-inactivated mice to bias their choices toward the higher-reward-probability target after changes in reward probability. Our results indicate, contrary to the traditional view, that the hippocampus, especially CA1, might contribute to incremental value learning under certain circumstances.
Advisors
Jung, Min Whanresearcher정민환researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2019.2,[v, 61 p. :]

Keywords

hippocampus▼aincremental value learning▼areinforcement learning▼alearning rate▼achemogenetic; 해마▼a점진적 가치학습▼a보상강화학습▼a학습률▼a화학유전학

URI
http://hdl.handle.net/10203/264814
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842106&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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