Dynamic prefrontal cortical neuronal activity supporting working memory for predictable and unpredictable durations = 예측 가능 및 예측 불가능한 시간 동안의 작업기억과 관련된 대뇌피질의 역동적인 신경활동

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Diverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1-7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed- and random-delay conditions. mPFC neurons conveyed higher working memory information under the random- than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results support the possibility that the mPFC relies on dynamically-changing neuronal population activity to maintain working memory regardless of the predictability of delay duration.
Advisors
Jung, Min Whanresearcher정민환researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2019.2,[v, 45 p. :]

Keywords

working memory▼arandom delay▼asequential firing▼amedial prefrontal cortex▼arat; 작업기억▼a임의지연기간▼a연속순차적인 발화▼a내측 전전두피질▼a쥐

URI
http://hdl.handle.net/10203/264813
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842096&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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