Advances in CRISPR-Cas systems for RNA targeting, tracking and editing

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dc.contributor.authorWang, Feiko
dc.contributor.authorWang, Lianrongko
dc.contributor.authorZou, Xuanko
dc.contributor.authorDuan, Sulingko
dc.contributor.authorLi, Zhiqiangko
dc.contributor.authorDeng, Zixinko
dc.contributor.authorLuo, Jieko
dc.contributor.authorLee, Sang Yupko
dc.contributor.authorChen, Shiko
dc.date.accessioned2019-08-22T02:20:04Z-
dc.date.available2019-08-22T02:20:04Z-
dc.date.created2019-08-19-
dc.date.created2019-08-19-
dc.date.issued2019-09-
dc.identifier.citationBIOTECHNOLOGY ADVANCES, v.37, no.5, pp.708 - 729-
dc.identifier.issn0734-9750-
dc.identifier.urihttp://hdl.handle.net/10203/264383-
dc.description.abstractClustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) systems, especially type II (Cas9) systems, have been widely used in gene/genome targeting. Modifications of Cas9 enable these systems to become platforms for precise DNA manipulations. However, the utilization of CRISPR-Cas systems in RNA targeting remains preliminary. The discovery of type VI CRISPR-Cas systems (Cas13) shed light on RNA-guided RNA targeting. Cas13d, the smallest Cas13 protein, with a length of only similar to 930 amino acids, is a promising platform for RNA targeting compatible with viral delivery systems. Much effort has also been made to develop Cas9, Cas13a and Cas13b applications for RNA-guided RNA targeting. The discovery of new RNA targeting CRISPR-Cas systems as well as the development of RNA-targeting platforms with Cas9 and Cas13 will promote RNA-targeting technology substantially. Here, we review new advances in RNA-targeting CRISPR-Cas systems as well as advances in applications of these systems in RNA targeting, tracking and editing. We also compare these Cas protein-based technologies with traditional technologies for RNA targeting, tracking and editing. Finally, we discuss remaining questions and prospects for the future.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleAdvances in CRISPR-Cas systems for RNA targeting, tracking and editing-
dc.typeArticle-
dc.identifier.wosid000477917000007-
dc.identifier.scopusid2-s2.0-85063660374-
dc.type.rimsART-
dc.citation.volume37-
dc.citation.issue5-
dc.citation.beginningpage708-
dc.citation.endingpage729-
dc.citation.publicationnameBIOTECHNOLOGY ADVANCES-
dc.identifier.doi10.1016/j.biotechadv.2019.03.016-
dc.contributor.localauthorLee, Sang Yup-
dc.contributor.nonIdAuthorWang, Fei-
dc.contributor.nonIdAuthorWang, Lianrong-
dc.contributor.nonIdAuthorZou, Xuan-
dc.contributor.nonIdAuthorDuan, Suling-
dc.contributor.nonIdAuthorLi, Zhiqiang-
dc.contributor.nonIdAuthorDeng, Zixin-
dc.contributor.nonIdAuthorLuo, Jie-
dc.contributor.nonIdAuthorChen, Shi-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorCRISPR-Cas systems-
dc.subject.keywordAuthorRNA targeting-
dc.subject.keywordAuthorRNA tracking-
dc.subject.keywordAuthorRNA editing-
dc.subject.keywordPlusDOUBLE-STRANDED-RNA-
dc.subject.keywordPlusLINKED MOLECULAR BEACONS-
dc.subject.keywordPlusNUCLEIC-ACID DETECTION-
dc.subject.keywordPlusMESSENGER-RNA-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusCRYSTAL-STRUCTURE-
dc.subject.keywordPlusGUIDED ENDONUCLEASE-
dc.subject.keywordPlusSPACER ACQUISITION-
dc.subject.keywordPlusDNA CLEAVAGE-
dc.subject.keywordPlusCMR COMPLEX-
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