Distinct roles of striatal direct and indirect pathways in value-based decision making

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dc.contributor.authorKwak, Shinaeko
dc.contributor.authorJung, Min Whanko
dc.date.accessioned2019-08-21T07:20:39Z-
dc.date.available2019-08-21T07:20:39Z-
dc.date.created2019-08-19-
dc.date.created2019-08-19-
dc.date.issued2019-07-
dc.identifier.citationELIFE, v.8, pp.1 - 16-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/10203/264358-
dc.description.abstractThe striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct-and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Inactivation of either D1R- or D2R-expressing striatal neurons impaired performance in both tasks, but the pattern of altered choice behavior differed between the two animal groups. A reinforcement learning model-based analysis indicated that inactivation of D1R- and D2R-expressing striatal neurons selectively impairs value-dependent action selection and value learning, respectively. Our results suggest differential contributions of striatal direct and indirect pathways to two distinct steps in value-based decision making.-
dc.languageEnglish-
dc.publisherELIFE SCIENCES PUBLICATIONS LTD-
dc.titleDistinct roles of striatal direct and indirect pathways in value-based decision making-
dc.typeArticle-
dc.identifier.wosid000477604100001-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.beginningpage1-
dc.citation.endingpage16-
dc.citation.publicationnameELIFE-
dc.identifier.doi10.7554/eLife.46050-
dc.contributor.localauthorJung, Min Whan-
dc.contributor.nonIdAuthorKwak, Shinae-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusBASAL GANGLIA-
dc.subject.keywordPlusDORSAL STRIATUM-
dc.subject.keywordPlusDOPAMINE-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusREWARD-
dc.subject.keywordPlusREINFORCEMENT-
dc.subject.keywordPlusRECEPTORS-
dc.subject.keywordPlusMOVEMENT-
dc.subject.keywordPlusFLEXIBILITY-
dc.subject.keywordPlusACTIVATION-
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