Janus Microcarriers for Magnetic Field-Controlled Combination Chemotherapy of Hepatocellular Carcinoma

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Combination chemotherapy administering multiple chemo agents is widely exploited for the treatment of various cancers in the clinic. Specially for hepatocellular carcinoma (HCC), one of the most common malignancies, a coadministration of combinational cytostatic multikinase inhibitors and cytotoxic chemo agents has been suggested as a potential curative approach. Here, Janus microcarriers are developed for the controlled local combination chemotherapy of HCC. The Janus microcarriers are composed of a polycaprolactone (PCL) compartment and a magnetic nanoparticle-loaded poly(lactide-co-glycolic acid) (PLGA) compartment which contains hydrophobic regorafenib and hydrophilic doxorubicin, respectively. Exploiting the magnetic anisotropy, rotational motion of the Janus microcarriers is controlled with a magnetic field, which enables the active corelease of dual chemo agents. Furthermore, Janus microcarriers exhibit magnetic resonance (MR) contrast effect, supporting the successful transcatheter intra-arterial delivery of the combination chemo agents loaded in the microcarriers to the targeted tumor. This Janus microcarrier potentially serves as a general combinational chemotherapeutic platform for the codelivery of various combinations of multichemo agents.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2019-06
Language
English
Article Type
Article
Citation

ADVANCED FUNCTIONAL MATERIALS, v.29, no.26

ISSN
1616-301X
DOI
10.1002/adfm.201901384
URI
http://hdl.handle.net/10203/264341
Appears in Collection
CBE-Journal Papers(저널논문)
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