Nicotinamide adenine dinucleotide as a photocatalyst

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dc.contributor.authorKim, Jinhyunko
dc.contributor.authorLee, Sahng Hako
dc.contributor.authorTieves, Florianko
dc.contributor.authorPaul, Caroline E.ko
dc.contributor.authorHollmann, Frankko
dc.contributor.authorPark, Chan Beumko
dc.date.accessioned2019-08-20T06:20:27Z-
dc.date.available2019-08-20T06:20:27Z-
dc.date.created2019-08-19-
dc.date.issued2019-07-
dc.identifier.citationSCIENCE ADVANCES, v.5, no.7-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10203/264334-
dc.description.abstractNicotinamide adenine dinucleotide (NAD(+)) is a key redox compound in all living cells responsible for energy transduction, genomic integrity, life-span extension, and neuromodulation. Here, we report a new function of NAD(+) as a molecular photocatalyst in addition to the biological roles. Our spectroscopic and electrochemical analyses reveal light absorption and electronic properties of two pi-conjugated systems of NAD(+). Furthermore, NAD(+) exhibits a robust photostability under UV-Vis-NIR irradiation. We demonstrate photocatalytic redox reactions driven by NAD(+), such as O-2 reduction, H2O oxidation, and the formation of metallic nanoparticles. Beyond the traditional role of NAD(+) as a cofactor in redox biocatalysis, NAD(+) executes direct photoactivation of oxidoreductases through the reduction of enzyme prosthetic groups. Consequently, the synergetic integration of biocatalysis and photocatalysis using NAD(+) enables solar-to-chemical conversion with the highest-ever-recorded turnover frequency and total turnover number of 1263.4 hour(-1) and 1692.3, respectively, for light-driven biocatalytic trans-hydrogenation.-
dc.languageEnglish-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleNicotinamide adenine dinucleotide as a photocatalyst-
dc.typeArticle-
dc.identifier.wosid000478770400110-
dc.identifier.scopusid2-s2.0-85069946816-
dc.type.rimsART-
dc.citation.volume5-
dc.citation.issue7-
dc.citation.publicationnameSCIENCE ADVANCES-
dc.identifier.doi10.1126/sciadv.aax0501-
dc.contributor.localauthorPark, Chan Beum-
dc.contributor.nonIdAuthorTieves, Florian-
dc.contributor.nonIdAuthorPaul, Caroline E.-
dc.contributor.nonIdAuthorHollmann, Frank-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusWATER OXIDATION-
dc.subject.keywordPlusLIGHT-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusNAD(+)-
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