Polypeptide binding to extracellular domain of epidermal growth factor receptor 상피세포 성장인자 수용체의 세포외 도메인과 결합하는 신규 폴리펩타이드

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The present invention relates to a polypeptide capable of binding specifically to the extracellular domain of epidermal growth factor receptor, a polynucleotide that encodes the polypeptide, an expression vector comprising the polynucleotide, a recombinant microorganism having the expression vector introduced therein, and a method of producing the polypeptide using the recombinant microorganism. The polypeptide according to the present invention can bind to the extracellular domain of epidermal growth factor receptor with a high binding affinity comparable to those of existing monoclonal antibodies that are widely used as targeted therapeutic agents, thereby inhibiting the activity of the epidermal growth factor receptor. The polypeptide is useful for the development of agents for the prevention or diseases associated with overexpression of epidermal growth factor receptor.
Assignee
KAIST
Country
US (United States)
Issue Date
2019-07-30
Application Date
2015-05-21
Application Number
15310585
Registration Date
2019-07-30
Registration Number
10364293
URI
http://hdl.handle.net/10203/264137
Appears in Collection
BS-Patent(특허)
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