The terrain features and surface characteristics are the most important elements not only in meteorological modeling but also in air quality modeling. The diurnal evolution of local climate over complex terrain may be significantly controlled by the ground irregularities. Such topographic features can affect a thermally driven flow, either directly by causing changes in the wind direction or indirectly, by inducing significant variations in the ground temperature. Over a complex terrain, these variations are due to the nonuniform distribution of solar radiation, which is highly determined by the ground geometrical characteristics, i.e. slope and orientation. Therefore, the accuracy of prediction of regional scale circulation is strong associated with the accuracy of land-use and topographic information in meso-scale circulation assessment. The objective of this work is a numerical simulation using MM5-A2C model with the detailed topography and land-use information as the surface boundary conditions of the air flow field in mountain regions. Meteorological conditions estimated by MM5-A2C command a great influence on the dispersion of mountain areas with the reasonable feature of topography where there is an important difference in orographic forcing.