The present invention relates to a kind of prevention of the hepatopathy of Ginsenoside F2, improvement or therapeutical uses and utilize its pharmaceutical composition, healthy functions food, feed composition; Ginsenoside F2 inhibits that fat is formed and accumulated in liver; increase the distribution for the active regulatory T cells for inhibiting inflammatory cell and protects liver; increase the expression of anti-inflammatory cytokines IL-10 in regulatory T cells; inhibit from naive T cell differentiating into T h17 cells, so as to effectively treat various hepatopathys.