Disclosed is a method for acquiring synchronization in a mobile communication system using an Orthogonal Frequency Division Multiplexing (OFDM) scheme. The method includes modeling a power delay profile in time-varying frequency selective fading channel conditions by a specific function; detecting a log probability distribution function of a timing offset and a frequency offset in consideration of a correlation between a received signal and the received multi-path signal in the time-varying frequency selective fading channel conditions having the power delay profile modeled as the specific function; and estimating a timing offset and a frequency offset which maximize the log probability distribution function of the timing offset and the frequency offset.