Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

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dc.contributor.authorKim, Jaeryungko
dc.contributor.authorPark, Jang Ryulko
dc.contributor.authorChoi, Jeongwoonko
dc.contributor.authorPark, Intaeko
dc.contributor.authorHwang, Yoonhako
dc.contributor.authorBae, Hosungko
dc.contributor.authorKim, Yongjooko
dc.contributor.authorChoi, WooJhonko
dc.contributor.authorYan, Jee Myungko
dc.contributor.authorHan, Sangyeulko
dc.contributor.authorChung, Tae-Youngko
dc.contributor.authorKim, Pilhanko
dc.contributor.authorKubota, Yoshiakiko
dc.contributor.authorAugustin, Hellmut G.ko
dc.contributor.authorOh, Wang-Yuhlko
dc.contributor.authorKoh, Gou Youngko
dc.date.accessioned2019-03-20T00:59:41Z-
dc.date.available2019-03-20T00:59:41Z-
dc.date.created2019-03-18-
dc.date.issued2019-02-
dc.identifier.citationSCIENCE ADVANCES, v.5, no.2-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10203/251996-
dc.description.abstractChoriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the treatment could exacerbate choriocapillary rarefaction, necessitating advanced treatment for fundamental recovery from NV-AMD. In this study, Tie2 activation by angiopoietin-2-binding and Tie2-activating antibody (ABTAA) presents a therapeutic strategy for NV-AMD. Conditional Tie2 deletion impeded choriocapillary maintenance, rendering eyes susceptible to NV-AMD development. Moreover, in a NV-AMD mouse model, ABTAA not only suppressed choroidal neovascularization (CNV) and vascular leakage but also regenerated the choriocapillaris and relieved hypoxia. Conversely, VEGF blockade degenerated the choriocapillaris and exacerbated hypoxia, although it suppressed CNV and vascular leakage. Together, we establish that angiopoietin-Tie2 signaling is critical for choriocapillary maintenance and that ABTAA represents an alternative, combinative therapeutic strategy for NV-AMD by alleviating anti-VEGF adverse effects.-
dc.languageEnglish-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleTie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration-
dc.typeArticle-
dc.identifier.wosid000460145700030-
dc.identifier.scopusid2-s2.0-85061970290-
dc.type.rimsART-
dc.citation.volume5-
dc.citation.issue2-
dc.citation.publicationnameSCIENCE ADVANCES-
dc.identifier.doi10.1126/sciadv.aau6732-
dc.contributor.localauthorKim, Pilhan-
dc.contributor.localauthorOh, Wang-Yuhl-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorChoi, WooJhon-
dc.contributor.nonIdAuthorYan, Jee Myung-
dc.contributor.nonIdAuthorHan, Sangyeul-
dc.contributor.nonIdAuthorChung, Tae-Young-
dc.contributor.nonIdAuthorKubota, Yoshiaki-
dc.contributor.nonIdAuthorAugustin, Hellmut G.-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSUPPRESSES CHOROIDAL NEOVASCULARIZATION-
dc.subject.keywordPlusINTRAOCULAR-PRESSURE-
dc.subject.keywordPlusBLOOD-FLOW-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusVEGF-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusANGIOPOIETIN-1-
dc.subject.keywordPlusBREAKDOWN-
Appears in Collection
NT-Journal Papers(저널논문)ME-Journal Papers(저널논문)MSE-Journal Papers(저널논문)
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