Combined Positive and Negative Feedback Allows Modulation of Neuronal Oscillation Frequency during Sensory Processing

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 88
  • Download : 4
A key step in sensory information processing involves modulation and integration of neuronal oscillations in disparate frequency bands, a poorly understood process. Here, we investigate how top-down input causes frequency changes in slow oscillations during sensory processing and, in turn, how the slow oscillations are combined with fast oscillations (which encode sensory input). Using experimental connectivity patterns and strengths of interneurons, we develop a system-level model of a neuronal circuit controlling these oscillatory behaviors, allowing us to understand the mechanisms responsible for the observed oscillatory behaviors. Our analysis discovers a circuit capable of producing the observed oscillatory behaviors and finds that a detailed balance in the strength of synaptic connections is the critical determinant to produce such oscillatory behaviors. We not only uncover how disparate frequency bands are modulated and combined but also give insights into the causes of abnormal neuronal activities present in brain disorders.
Publisher
CELL PRESS
Issue Date
2018-11
Language
English
Article Type
Article
Keywords

VISUAL CORTICAL AREAS; INHIBITORY NEURONS; SOMATOSENSORY CORTEX; SIGNALING PATHWAYS; GAMMA-OSCILLATIONS; GABAERGIC NEURONS; SYSTEMS BIOLOGY; MOUSE NEOCORTEX; BARREL CORTEX; LAYER 2/3

Citation

CELL REPORTS, v.25, no.6, pp.1548 - 1560

ISSN
2211-1247
DOI
10.1016/j.celrep.2018.10.029
URI
http://hdl.handle.net/10203/247122
Appears in Collection
BiS-Journal Papers(저널논문)
Files in This Item
Combined Positive and Negative Feedback AllowsModulation of Neuronal Oscillation Frequency duringSensory Processing.pdf(5.42 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0