Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy

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High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge in neuroscience. Here we demonstrate simultaneous functional imaging of neuronal activity at single-neuron resolution in an entire Caenorhabditis elegans and in larval zebrafish brain. Our technique captures the dynamics of spiking neurons in volumes of similar to 700 mu m x 700 mu m x 200 mu m at 20 Hz. Its simplicity makes it an attractive tool for high-speed volumetric calcium imaging.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2014-07
Language
English
Article Type
Article
Citation

NATURE METHODS, v.11, no.7, pp.727 - U161

ISSN
1548-7091
DOI
10.1038/NMETH.2964
URI
http://hdl.handle.net/10203/247009
Appears in Collection
EE-Journal Papers(저널논문)
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