Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-beta expression and fibroblast recruitment

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We describe surgical sutures enabled with the local, sustained delivery of a TGF-beta inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly (lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-beta expression and fibroblast numbers during the entire 21 day testing period. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2018-11
Language
English
Article Type
Article
Keywords

GROWTH-FACTORS; FIBROSIS; SKIN; SUPPRESSION; RELEASE; KELOIDS; MODEL

Citation

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.67, pp.469 - 477

ISSN
1226-086X
DOI
10.1016/j.jiec.2018.07.021
URI
http://hdl.handle.net/10203/246686
Appears in Collection
BiS-Journal Papers(저널논문)
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