In-droplet microparticle washing and enrichment using surface acoustic wave-driven acoustic radiation force

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Washing and enrichment of particles and cells are crucial sample preparation procedures in biomedical and biochemical assays. On-chip in-droplet microparticle washing and enrichment have been pursued but remained problematic due to technical difficulties, especially simultaneous and precise control over the droplet interface and in-droplet samples. Here, we have achieved a breakthrough in label-free, continuous, on-demand, in-droplet microparticle washing and enrichment using surface acoustic waves. When exposed to the acoustic field, the droplet and suspended particles experience acoustic radiation force arising from inhomogeneous wave scattering at the liquid/liquid and liquid/solid interfaces. Based on these acoustophoretic phenomena, we have demonstrated in-droplet microparticle washing and enrichment in an acoustofluidic device. We expect that the proposed acoustic method will offer new perspectives to sample washing and enrichment by performing the operation in microscale droplets.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2018-08
Language
English
Article Type
Article
Keywords

DISPOSABLE MICROFLUIDIC CHIP; CIRCULATING TUMOR-CELLS; CONTINUOUS-FLOW; MEDIUM EXCHANGE; SEPARATION; MANIPULATION; SIZE; PARTICLES; DIELECTROPHORESIS; ACOUSTOPHORESIS

Citation

LAB ON A CHIP, v.19, no.19, pp.2936 - 2945

ISSN
1473-0197
DOI
10.1039/C8LC00733K
URI
http://hdl.handle.net/10203/246344
Appears in Collection
ME-Journal Papers(저널논문)
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