DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kayoung | ko |
dc.contributor.author | Lee, Sahng Ha | ko |
dc.contributor.author | Choi, Da Som | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.date.accessioned | 2018-11-12T04:18:11Z | - |
dc.date.available | 2018-11-12T04:18:11Z | - |
dc.date.created | 2018-10-22 | - |
dc.date.created | 2018-10-22 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | ADVANCED FUNCTIONAL MATERIALS, v.28, no.41 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | http://hdl.handle.net/10203/246312 | - |
dc.description.abstract | Bismuth vanadate (BiVO4) is an attractive, low-cost n-type semiconductor that exhibits excellent photoelectrocatalytic properties, chemical stability, and biocompatibility. This study reports a newly discovered function of BiVO4 dissociating highly stable, self-assembled amyloid aggregates associated with Alzheimer's disease. A visible light-active, nanoporous BiVO4 platform is developed to break -amyloid (A beta) assemblies and alleviate A aggregate-induced toxicity. Multiple photochemical and microscopic analyses reveal that beta-sheet-rich, long A beta fibrils are effectively destabilized and broken into small-sized, soluble species by BiVO4 photoelectrode under illumination of a white light-emitting diode and an anodic bias. The photoactivated BiVO4 under anodic bias generates oxidative stress, such as superoxide ions and hole-derived hydrogen peroxide, which causes photooxidation of A beta residues and irreversible disassembly of A beta aggregates. The efficacy of photoelectrocatalytic dissociation of A beta aggregates is enhanced by Mo-doped BiVO4, which facilitates the separation of electron-hole pairs by improving electron-transport properties of BiVO4. Furthermore, it is verified that both pristine and Mo-doped BiVO4 photoelectrodes are nontoxic and effective in reducing A beta-associated cytotoxicity. The work shows the potential of BiVO4-based photoelectrode platforms for the dissociation of neurotoxic, highly stable A beta assemblies using light energy. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | SOLAR WATER OXIDATION | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | BIVO4 PHOTOANODES | - |
dc.subject | ELECTROCHEMICAL SYNTHESIS | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | CIRCULAR-DICHROISM | - |
dc.subject | FIBRIL FORMATION | - |
dc.subject | PROTEIN | - |
dc.subject | NEUROTOXICITY | - |
dc.subject | OLIGOMERS | - |
dc.title | Photoactive Bismuth Vanadate Structure for Light-Triggered Dissociation of Alzheimer's beta-Amyloid Aggregates | - |
dc.type | Article | - |
dc.identifier.wosid | 000446550700006 | - |
dc.identifier.scopusid | 2-s2.0-85052621017 | - |
dc.type.rims | ART | - |
dc.citation.volume | 28 | - |
dc.citation.issue | 41 | - |
dc.citation.publicationname | ADVANCED FUNCTIONAL MATERIALS | - |
dc.identifier.doi | 10.1002/adfm.201802813 | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | bismuth vanadate | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | peptide self-assembly | - |
dc.subject.keywordAuthor | photocatalysis | - |
dc.subject.keywordPlus | SOLAR WATER OXIDATION | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | BIVO4 PHOTOANODES | - |
dc.subject.keywordPlus | ELECTROCHEMICAL SYNTHESIS | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | FIBRIL FORMATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | OLIGOMERS | - |
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