A Near-Infrared Fluorescent Probe for Amyloid-β Aggregates

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The deposition of amyloid-β (Aβ) aggregates in the brain is a hallmark of the Alzheimer's disease (AD)-affected brain. Various aggregated Aβ species, including oligomers and fibrils, are generated upon the aggregation process, and these Aβ aggregates have distinct biological properties. To non-invasively monitor the aggregation pathways of Aβ and identify the existence of certain Aβ species in biological environments, an effective strategy to detect Aβ species is necessary. Herein, we report a turn-on near-infrared (near-IR) fluorescent probe, 1, for Aβ aggregates, which consists of a donor-π-acceptor system with an Aβ-interacting moiety. Our probe, 1, shows a noticeable increase in near-IR fluorescence at ca. 710 nm in the presence of Aβ aggregates in aqueous media. In addition, the fluorescent response of 1 was altered depending on the degree of Aβ aggregation. Moreover, 1 indicates turn-on fluorescence with Aβ aggregates in living cells and is nontoxic under the condition used for live-cell imaging.
Publisher
ELSEVIER SCI LTD
Issue Date
2019-03
Language
English
Citation

DYES AND PIGMENTS, v.162, pp.97 - 103

ISSN
0143-7208
DOI
10.1016/j.dyepig.2018.10.013
URI
http://hdl.handle.net/10203/246289
Appears in Collection
CH-Journal Papers(저널논문)
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