PurposeThe routine MRI scan protocol consists of multiple pulse sequences that acquire images of varying contrast. Since high frequency contents such as edges are not significantly affected by image contrast, down-sampled images in one contrast may be improved by high resolution (HR) images acquired in another contrast, reducing the total scan time. In this study, we propose a new deep learning framework that uses HR MR images in one contrast to generate HR MR images from highly down-sampled MR images in another contrast. Materials and MethodsThe proposed convolutional neural network (CNN) framework consists of two CNNs: (a) a reconstruction CNN for generating HR images from the down-sampled images using HR images acquired with a different MRI sequence and (b) a discriminator CNN for improving the perceptual quality of the generated HR images. The proposed method was evaluated using a public brain tumor database and invivo datasets. The performance of the proposed method was assessed in tumor and no-tumor cases separately, with perceptual image quality being judged by a radiologist. To overcome the challenge of training the network with a small number of available invivo datasets, the network was pretrained using the public database and then fine-tuned using the small number of invivo datasets. The performance of the proposed method was also compared to that of several compressed sensing (CS) algorithms. ResultsIncorporating HR images of another contrast improved the quantitative assessments of the generated HR image in reference to ground truth. Also, incorporating a discriminator CNN yielded perceptually higher image quality. These results were verified in regions of normal tissue as well as tumors for various MRI sequences from pseudo k-space data generated from the public database. The combination of pretraining with the public database and fine-tuning with the small number of real k-space datasets enhanced the performance of CNNs in invivo application compared to training CNNs from scratch. The proposed method outperformed the compressed sensing methods. ConclusionsThe proposed method can be a good strategy for accelerating routine MRI scanning.