Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles

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Photoacoustic (PA) imaging allows visualization of the physiology and pathology of tissues with good spatial resolution and relatively deep tissue penetration. The method converts near-infrared (NIR) laser excitation into thermal expansion, generating pressure transients that are detected with an acoustic transducer. Here, we find that the response of the PA contrast agent indocyanine green (ICG) can be enhanced 17-fold when it is sealed within a rigid nanoparticle. ICG encapsulated in particles composed of porous silicon (pSiNP), porous silica, or calcium silicate all show greater PA contrast relative to equivalent quantities of free ICG, with the pSiNPs showing the strongest enhancement. A liposomal formulation of ICG performs similar to free ICG, suggesting that a rigid host nanostructure is necessary to enhance ICG performance. The improved response of the nanoparticle formulations is attributed to the low thermal conductivity of the porous inorganic hosts and their ability to protect the ICG payload from photolytic and/or thermal degradation. The translational potential of ICG-loaded pSiNPs as photoacoustic probes is demonstrated via imaging of a whole mouse brain.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2018-07
Language
English
Article Type
Article
Keywords

CONTRAST AGENTS; POROUS SILICON; INDOCYANINE GREEN; PHOTOTHERMAL THERAPY; NANOWIRES; DELIVERY; PROBES; TOOL

Citation

ADVANCED MATERIALS, v.30, no.27

ISSN
0935-9648
DOI
10.1002/adma.201800512
URI
http://hdl.handle.net/10203/244660
Appears in Collection
BiS-Journal Papers(저널논문)
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