Studies on the mechanisms for autonomic function regulation by Melanocortin-4 receptors = 멜라노코르틴 수용체에 의한 자율신경기능 조절 기전 연구

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Melanocortin-4 receptors (MC4Rs) regulate appetite and metabolism in the central nervous system. Loss-of-function mutation of MC4R results in hyperphagia, obesity, hyperinsulinemia, and decreased energy expenditure, both in human patients and model mice. As obese patients baring MC4R mutations are protected against hypertension, MC4Rs are regarded as a future key target for novel drug for obesity, diabetes, and hypertension. MC4Rs in the autonomic nervous system reciprocally regulate sympathetic and parasympathetic nervous system. A previous study revealed that MC4R agonist hyperpolarized neurons of the dorsal motor nucleus of the vagus nerve (DMV), whereas depolarized neurons of the intermediolateral cell column of the spinal cord (IML). However, detailed mechanism of MC4R action is still unknown. In this thesis, I studied detailed mechanisms of MC4R-mediated regulation of miniature postsynaptic currents in the autonomic nervous system with whole-cell patch clamp technique.
Advisors
Sohn, Jong Wooresearcher손종우researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2017.8,[ii, 30 p. :]

Keywords

melanocortin▼apatch clamp▼adiabetes▼ahypertension▼aautonomic nervous system▼aneurophysiology; 멜라노코르틴▼a패치클램프▼a당뇨▼a고혈압▼a자율신경계▼a신경생리학

URI
http://hdl.handle.net/10203/243052
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718611&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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