Generation of functional insulin-producing endocrine cells and clusters from human pluripotent stem cells = 인간 전분화능줄기세포로부터 인슐린 생산 내분비 세포 클러스터의 분화에 대한 연구

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 161
  • Download : 0
Diabetes is caused by the defective insulin secretion that leads to hyperglycemic condition. The considerable loss of pancreatic beta cells is the major reason of diabetes which makes the patients to depend on the exogenous supply of islets. The limited availability of cadaveric islet donors demands the need of other islet sources. Human embryonic stem cells (hESCs) are clonogenic cells capable of both self renewal and multi-lineage differentiation. Differentiating hESCs to insulin secreting pancreatic islet cells would therefore be of great importance in the studying and treatment of diabetes. This study focuses on the differentiation process of the human pluripotent stem cells to insulin producing cells and clusters. The detailed characterization of fully differentiated cells indicated the functionality of stem cell derived islets hence increasing the hope of diabetes reversal. The differentiation of the induced pluripotent stem cells to insulin producing cells which could open ways to autologous insulin-producing cells and also various other disease modeling and drug-screening strategies.
Advisors
Han, Yong-Mahnresearcher한용만researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2017.2,[v, 42 p. :]

Keywords

Diabetes Mellitus; Pancreas; Islets; Insulin; human pluripotent stem cells; 당뇨병; 췌장; 췌장 내분비 세포; 인슐린; 인간 전분화능줄기세포

URI
http://hdl.handle.net/10203/243050
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675239&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0