(A) role of the Hippo pathway in renal tubulointerstitial fibrosis eevelopment = 신세뇨관 간질성 섬유증에서의 Hippo 신호전달의 역할

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Renal tubulointerstitial fibrosis (TIF) is the final step of various renal injuries leading to chronic kidney disease. The mammalian Hippo-Salvador signaling pathway has been implicated in the control of cell proliferation, cell death, tissue regeneration, and tumorigenesis. However, the role of the mammalian Hippo pathway in TIF development has not been investigated. Here, I report that the Hippo-Salvador pathway plays a role in TIF development. An in vitro study using renal tubular cells, HK-2 cells, showed that SAV1 deficiency led to the increase of activity of YAP/TAZ, which induced the expression of $TGF-\beta 2$ and $TGF-\beta$ receptor II. Furthermore, SAV1 deficiency led to an induction of pro-fibrotic or EMT marker genes, mediating the increase of YAP/TAZ activity. Collectively, these results suggest that the Hippo pathway plays a role in the pathogenesis of TIF, and targeting this pathway may be a therapeutic strategy for reducing TIF.
Advisors
Lim, Dae-Sikresearcher임대식researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2017.2,[iii, 28 p. :]

Keywords

Kidney; Renal tubulointerstitial fibrosis (TIF); SAV1; TGF-β; β-catenin; the Hippo pathway; 신장; 신세뇨관 간질성 섬유증; Hippo 신호전달

URI
http://hdl.handle.net/10203/243047
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675244&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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