The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast

Cited 4 time in webofscience Cited 0 time in scopus
  • Hit : 146
  • Download : 0
Accumulating evidence shows that non-proteolytic functions of the proteasome are as crucial as its well-known proteolytic function in regulating cellular activities. In our recent work, we showed that the 19S proteasome mediates the heterochromatin spreading of centromeric heterochromatin in non-proteolytic manner. However, the involvement of the proteasome in other heterochromatin regions remained largely unknown. In the present study, we investigated the non-proteolytic role of the 19S proteasome in subtelomere and facultative heterochromatin regions. Using the non-proteolytic mutant, rpt4-1, we show that the 19S proteasome is involved in regulating subtelomere silencing and facultative heterochromatin formation in fission yeast. In addition to this proteasome-related regulation, we also observed a distinct pathway that regulates subtelomere silencing and facultative heterochromatin formation through the Paf1 complex subunit, Leo1. Our comparison of the two pathways revealed a new group of heterochromatin domains that are regulated exclusively by the proteasome pathway. Taken together, our findings reveal that the proteasome is involved in the global regulation of facultative and constitutive heterochromatin.
Publisher
SPRINGER
Issue Date
2018-06
Language
English
Article Type
Article
Keywords

JMJC DOMAIN PROTEIN; RNA-POLYMERASE-II; GENE-EXPRESSION; 26S PROTEASOME; SCHIZOSACCHAROMYCES-POMBE; HISTONE ACETYLTRANSFERASE; EPIGENETIC CONTROL; ACTIVE CHROMATIN; QUALITY-CONTROL; UBIQUITIN

Citation

CURRENT GENETICS, v.64, no.3, pp.741 - 752

ISSN
0172-8083
DOI
10.1007/s00294-017-0792-6
URI
http://hdl.handle.net/10203/242453
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 4 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0