(A) synthesis of enantiopure mixed Alkyl-Aryl diamines and (+)-CP-99,994 (B) ligand effect for Pd-catalyzed cross-coupling reactions = (A) 혼합된 알킬-아릴 다이아민과 (+)-CP-99,994의 입체선택적 합성 (B) 팔라듐 촉매 교차-결합 반응에서의 리간드 효과

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The development of efficient catalysts and reaction conditions is important to improve reactivity and selectivity in organic chemistry. In this thesis, a stereoselective synthesis of enantiopure mixed alkyl-aryl by the diaza-Cope rearrangement reaction and their application for an efficient synthesis of bioactive compounds such as cisplatin analogues and (+)-CP-99,994 are described. Also, highly reactive catalysts are prepared for Buchwald-Hartwig amination reactions by synergistic ligand effect between N-heterocyclic carbine (NHC) and bicyclic bridgehead phosphoramidite ligands(briphos). Lastly, the influence of a bidentate ligand which shows high reactivity and regioselectivity in Pd-catalyzed dimerization of cinnamyl bromides is demonstrated.
Advisors
Kim, Hyunwooresearcher김현우researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2017.2,[ii, 65 p. :]

Keywords

diamine; (+)-CP-99; 994; palladium; Buchwald-Hartwig amination reaction; dimerization reaction; 다이아민; 팔라듐; 부크발트-하트윅 아민화 반응; 이합체화 반응

URI
http://hdl.handle.net/10203/242152
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675879&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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