Microfluidic designing of polymeric microcapsules with size-selective permeability = 크기 선택적 투과 특성을 갖는 고분자 마이크로캡슐의 미세유체공학적 설계

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dc.contributor.advisorKim, Shin-Hyun-
dc.contributor.advisor김신현-
dc.contributor.authorKim, Bomi-
dc.contributor.author김보미-
dc.date.accessioned2018-05-23T19:35:06Z-
dc.date.available2018-05-23T19:35:06Z-
dc.date.issued2017-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675734&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/241873-
dc.description학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2017.2,[vii, 92 p. :]-
dc.description.abstractSemipermeable microcapsules have a great potential in protection of catalysts, controlled release of drugs, and platform for microcapsule type sensor. However, a method to create such microcapsules with precisely controlled cut-off value and high mechanical stability remains an important challenge. Here in we report three microfluidic approaches to create polymer microcapsules with size-selective permeability. First approach is to utilize phase separation of homopolymer blends in ultra-thin middle layer of double-emulsion drops. The blend strongly confined in two-dimensional space exhibit local phase separation, instead of global separation. This enables the perforation of microcapsule membrane by selectively removing one of the phase-separated polymeric domains. The resultant monolithic membrane has uniform pores which connect the interior and the exterior of the microcapsules, thereby providing size-selective permeability. The pore size can be precisely tuned by regulating the extent of phase separation-
dc.description.abstractthis enables the control of cutoff value for permeation. Second approach is to employ polymerization-induced phase separation between crosslinked polymer and oil to enhance organic solvent resistance and biocompatibility of the microcapsules. Upon UV illumination on double-emulsion drops whose ultrathin middle layer is composed of photocurable resin and inert oil, the monomers are photopolymerized, which leads to phase separation between the polymerized resin and the oil within the ultrathin shell. Subsequent dissolution of the oil leaves behind regular pores in the polymerized membrane providing size-selective permeability. The degree of phase separation can be further tuned by adjusting the fraction of oil in the shell or the affinity of the oil to the monomers, thereby enabling the control of the cutoff value of permeation. Finally, I suggest polymerization-induced microphase separation with in situ block polymer formation approach for creating semipermeable microcapsules which has more delicate controllability over size and porosity of porous membrane. Copolymerization of styrene and divinylbenzene (DVB) in the presence of PLA macro-chain transfer agent (PLA-CTA) via reversible addition-fragmentation chain transfer (RAFT) process produced a crosslinked PS-b-PLA precursor with a disordered bicontinuous morphology consisting of PS and PLA microdomains, and PLA etching out of the precursor yielded the desired nanoporous membrane. Pore size is finely controlled by varying molecular weight of PLA block in a range of 5-30 nm. We introduce three different strategy of fabricating semipermeable microcapsule with controlled permeability. High mechanical stability and chemical resistance of the microcapsules, as well as controllable permeability and high encapsulation efficiency, will provide new opportunity in a wide range of applications.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectDouble emulsion-
dc.subjectDroplet-based microfluidics-
dc.subjectPolymer microcapsule-
dc.subjectSemipermeable microcapsule-
dc.subjectPolymer phase separation-
dc.subjectPolymerization-induced microphase separation-
dc.subject이중액적-
dc.subject미세유체공학-
dc.subject고분자 마이크로캡슐-
dc.subject반투과성 마이크로캡슐-
dc.subject고분자 상분리-
dc.subject중합유도상분리-
dc.titleMicrofluidic designing of polymeric microcapsules with size-selective permeability = 크기 선택적 투과 특성을 갖는 고분자 마이크로캡슐의 미세유체공학적 설계-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :생명화학공학과,-
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