Photothermally Amplified Therapeutic Liposomes for Effective Combination Treatment of Cancer

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Near-infrared photothermal therapy has been investigated extensively with regard to selective tumor eradication, yet its clinical translation has been limited because of the absence of FDA-approvable agents with effective phototherapeutic function and minimal systemic toxicity. In this work, we developed photothermally amplified therapeutic liposomes in an attempt to synergize chemotherapy and hyperthermia for effective cancer phototherapy. The anticancer drug cisplatin and the photothermal agent indocyanine green (ICG) were encapsulated in a thermosensitive liposomal formulation at the lipid/ICG ratio maximizing the ICG loading efficiency. These liposomes released cytotoxic cisplatin molecules selectively via ICG-mediated photothermal stimulation. In phototherapeutic studies, these liposomes amplified therapeutic effects both in vitro in cancer cells and in vivo in mouse tumor models significantly over chemotherapy or photothermal therapy alone. We believe that these photothermally amplified therapeutic liposomes composed solely of already FDA-approved components (cisplatin, ICG, and phospholipids) have enormous potential for clinical translation in treating various tumors compatible with laser irradiation.
Publisher
AMER CHEMICAL SOC
Issue Date
2018-02
Language
English
Article Type
Article
Keywords

IN-VIVO; INDOCYANINE GREEN; DRUG-RELEASE; NANOPARTICLES; HYPERTHERMIA; TUMORS; CHEMOTHERAPY; NANOSPHERES; SYSTEM; LASER

Citation

ACS APPLIED MATERIALS & INTERFACES, v.10, no.7, pp.6118 - 6123

ISSN
1944-8244
DOI
10.1021/acsami.7b15996
URI
http://hdl.handle.net/10203/240967
Appears in Collection
BiS-Journal Papers(저널논문)
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