Detection of Fast Oscillating Magnetic Fields using Dynamic Multiple TR Imaging and Fourier Analysis

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Neuronal oscillations produce oscillating magnetic fields. There have been trials to detect neuronal oscillations using MRI, but the detectability in in vivo is still in debate. Major obstacles to detecting neuronal oscillations are (i) weak amplitudes, (ii) fast oscillations, which are faster than MRI temporal resolution, and (iii) random frequencies and on/off intervals. In this study, we proposed a new approach for direct detection of weak and fast oscillating magnetic fields. The approach consists of (i) dynamic acquisitions using multiple times to repeats (TRs) and (ii) an expanded frequency spectral analysis. Gradient echo echo-planar imaging was used to test the feasibility of the proposed approach with a phantom generating oscillating magnetic fields with various frequencies and amplitudes and random on/off intervals. The results showed that the proposed approach could precisely detect the weak and fast oscillating magnetic fields with random frequencies and on/off intervals. Complex and phase spectra showed reliable signals, while no meaningful signals were observed in magnitude spectra. A two-TR approach provided an absolute frequency spectrum above Nyquist sampling frequency pixel by pixel with no a priori target frequency information. The proposed dynamic multiple-TR imaging and Fourier analysis are promising for direct detection of neuronal oscillations and potentially applicable to any pulse sequences.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2018-01
Language
English
Article Type
Article
Keywords

NEURONAL CURRENT MRI; RESTING-STATE NETWORKS; HUMAN BRAIN; FUNCTIONAL CONNECTIVITY; BLOOD OXYGENATION; VISUAL-CORTEX; MOTOR CORTEX; CURRENTS; SIGNAL; BOLD

Citation

PLOS ONE, v.13, no.1, pp.e0189916.

ISSN
1932-6203
DOI
10.1371/journal.pone.0189916
URI
http://hdl.handle.net/10203/240113
Appears in Collection
BiS-Journal Papers(저널논문)
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