Microfluidic neural probes: in vivo tools for advancing neuroscience

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Microfluidic neural probes hold immense potential as in vivo tools for dissecting neural circuit function in complex nervous systems. Miniaturization, integration, and automation of drug delivery tools open up new opportunities for minimally invasive implants. These developments provide unprecedented spatiotemporal resolution in fluid delivery as well as multifunctional interrogation of neural activity using combined electrical and optical modalities. Capitalizing on these unique features, microfluidic technology will greatly advance in vivo pharmacology, electrophysiology, optogenetics, and optopharmacology. In this review, we discuss recent advances in microfluidic neural probe systems. In particular, we will highlight the materials and manufacturing processes of microfluidic probes, device configurations, peripheral devices for fluid handling and packaging, and wireless technologies that can be integrated for the control of these microfluidic probe systems. This article summarizes various microfluidic implants and discusses grand challenges and future directions for further developments.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2017-04
Language
English
Article Type
Review
Keywords

DRUG-DELIVERY SYSTEMS; WIRELESS POWER TRANSFER; ENABLE OPTICAL CONTROL; FREELY MOVING ANIMALS; HUMAN BRAIN PROJECT; MICRO-CHANNELS; THERMOPNEUMATIC MICROPUMP; EXPANDABLE MICROSPHERES; BIOMEDICAL APPLICATIONS; SURFACE MODIFICATION

Citation

LAB ON A CHIP, v.17, no.8, pp.1406 - 1435

ISSN
1473-0197
DOI
10.1039/c7lc00103g
URI
http://hdl.handle.net/10203/238847
Appears in Collection
EE-Journal Papers(저널논문)
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