Coating of an antimicrobial peptide on solid substrate via initiated chemical vapor deposition

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We developed a simple and efficient method for the immobilization of a potent AMP (SHAP1) on the surface of solid supports via initiated chemical vapor deposition (iCVD). The surface of the slide glass was functionalized with vinyl-containing polymer by iCVD, and Cys-linked SHAP1 peptides could be immobilized on the functionalized surface (glass and latex glove) via simple thiol-ene click chemistry with high efficiency. The antimicrobial efficacy of the immobilized peptides was investigated against two typical pathogenic bacteria — Escherichia coli and Staphylococcus aureus — and it was revealed that SHAP1-GS-Cys exhibited high antibacterial efficacy (>96%).
Publisher
ELSEVIER SCIENCE INC
Issue Date
2018-02
Language
English
Article Type
Article
Citation

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.58, pp.51 - 56

ISSN
1226-086X
DOI
10.1016/j.jiec.2017.09.006
URI
http://hdl.handle.net/10203/237810
Appears in Collection
CBE-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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