Novel amine-functionalized iron trimesates with enhanced peroxidase-like activity and their applications for the fluorescent assay of choline and acetylcholine

We herein describe novel amine-grafted metal organic frameworks (MOFs) as a promising alternative to natural peroxidase enzyme and their applications for a fluorescent assay of choline (Cho) and acetylcholine (ACh). Among diverse amine-functionalized MOFs, N,N,N',N'-tetramethyl-1,4-butanediamine (TMBDA)-functionalized MIL-100(Fe) (TMBDA-MIL-100(Fe)) exhibited the highest peroxidase activity by developing intense fluorescence from Amplex UltraRed (AUR) in the presence of H2O2, which was presumably due to the synergetic effect of the enhanced negative potential and precisely controlled molecular size of the grafted diamine. Based on the excellent peroxidase-like activity of TMBDA-MIL-100(Fe), choline and ACh were reliably determined down to 0.027 and 0.036 mu M, respectively. Furthermore, practical applicability of this strategy was successfully demonstrated by detecting choline and ACh in spiked samples of milk and serum, respectively. This work highlights the advantages of amine-grafted MOFs for the preparation of biomimetic catalysts, extending their scope to biosensor applications.
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Issue Date
2018-02
Language
English
Article Type
Article
Keywords

METAL-ORGANIC FRAMEWORK; CERIUM OXIDE NANOPARTICLES; COLORIMETRIC DETECTION; HORSERADISH-PEROXIDASE; MAGNETIC NANOPARTICLES; CATALYTIC-ACTIVITY; GRAPHENE OXIDE; PLATINUM NANOPARTICLES; BIOSENSING PLATFORM; HYDROGEN-PEROXIDE

Citation

BIOSENSORS & BIOELECTRONICS, v.100, pp.161 - 168

ISSN
0956-5663
DOI
10.1016/j.bios.2017.08.056
URI
http://hdl.handle.net/10203/228563
Appears in Collection
CBE-Journal Papers(저널논문)
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