Percolation transition of cooperative mutational effects in colorectal tumorigenesis

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Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modules in the network undergoes a percolation transition, a sudden critical transition from scattered small modules to a large connected cluster, during colorectal tumorigenesis. Such a large cluster ultimately results in a giant percolated cluster, which is accompanied by phenotypic changes corresponding to cancer hallmarks. Moreover, we find that the most commonly observed sequence of driver mutations in colorectal cancer has been optimized to maximize the giant percolated cluster. Our network-level percolation study shows that the cooperative effect rather than any single dominance of multiple somatic mutations is crucial in colorectal tumorigenesis.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2017-11
Language
English
Article Type
Article
Citation

NATURE COMMUNICATIONS, v.8

ISSN
2041-1723
DOI
10.1038/s41467-017-01171-6
URI
http://hdl.handle.net/10203/227189
Appears in Collection
BiS-Journal Papers(저널논문)
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