Recently, a new type of main control room (MCR) has been adopted in nuclear power plants (NPPs). The new MCR, known as the advanced MCR, consists of digitalized human-system interfaces (HSIs), computer-based procedures (CPS), and soft controls while the conventional MCR includes many alarm tiles, analog indicators, hard-wired control devices, and paper-based procedures. These changes significantly affect the generic activities of the MCR operators, in relation to diagnostic activities. The aim of this paper is to suggest a framework to estimate the probabilities of diagnosis errors in the advanced MCR by updating a time reliability correlation (TRC) model. Using Bayesian inference, the TRC model was updated with the probabilities of diagnosis errors. Here, the diagnosis error data were collected from a full-scope simulator of the advanced MCR. To do this, diagnosis errors were determined based on an information processing model and their probabilities were calculated. However, these calculated probabilities of diagnosis errors were largely affected by context factors such as procedures, HSI, training, and others, known as PSFs (Performance Shaping Factors). In order to obtain the nominal diagnosis error probabilities, the weightings of PSFs were also evaluated. Then, with the nominal diagnosis error probabilities, the TRC model was updated. This led to the proposal of a framework to estimate the nominal probabilities of diagnosis errors in the advanced MCR. (C) 2017 Elsevier Ltd. All rights reserved.