In vivo cellular-level real-time pharmacokinetic imaging of free-form and liposomal indocyanine green in liver

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Indocyanine green (ICG) is a near-infrared fluorophore approved for human use which has been widely used for various clinical applications. Despite the well-established clinical usage, our understanding about the microscopic in vivo pharmacokinetics of systemically administered ICG has been relatively limited. In this work, we successfully visualized real-time in vivo pharmacokinetic dynamics of the intravenously injected free-form and liposomal ICG in cellular resolution by utilizing a custom-built video-rate near infrared laser-scanning confocal microscopy system. Initial perfusion and clearance from blood stream, diffusion into perisinusoidal space, and subsequent absorption into hepatocyte were directly visualized in vivo. The quantification analysis utilizing the real-time image sequences revealed distinct dynamic in vivo pharmacokinetic behavior of free-form and liposomal ICG. (C) 2017 Optical Society of America
Publisher
OPTICAL SOC AMER
Issue Date
2017-10
Language
English
Article Type
Article
Keywords

CONFOCAL MICROSCOPY; LYMPHATIC FUNCTION; CARDIAC-OUTPUT; CANCER-CELLS; FLUORESCENCE; TUMOR; ICG; VISUALIZATION; TOMOGRAPHY; DRAINAGE

Citation

BIOMEDICAL OPTICS EXPRESS, v.8, no.10, pp.4706 - 4716

ISSN
2156-7085
DOI
10.1364/BOE.8.004706
URI
http://hdl.handle.net/10203/226608
Appears in Collection
BiS-Journal Papers(저널논문)NT-Journal Papers(저널논문)
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