Succinic acid production by continuous fermentation process using Mannheimia succiniciproducens LPK7

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To achieve a higher succinic acid productivity and evaluate the industrial applicability, this study used Mannheimia succiniciproducens LPK7 (knock-out: ldhA, pflB, pta-ackA), which was recently designed to enhance the productivity of succinic acid and reduce by-product secretion. Anaerobic continuous fermentation of Mannheimia succiniciproducens LPK7 was carried out at different glucose feed concentrations and dilution rates. After extensive fermentation experiments, a succinic acid yield and productivity of 0.38 mol/mol and 1.77 g/l/h, respectively, were achieved with a glucose feed concentration of 18.0 g/l and 0.2 h(-1) dilution rate. A similar amount of succinic acid production was also produced in batch culture experiments. Therefore, these optimal conditions can be industrially applied for the continuous production of succinic acid. To examine the quantitative balance of the metabolism, a flux distribution analysis was also performed using the metabolic network model of glycolysis and the pentose phosphate pathway.
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Issue Date
2008-05
Language
English
Article Type
Article
Keywords

ANAEROBIOSPIRILLUM-SUCCINICIPRODUCENS; WOOD HYDROLYSATE; BACTERIUM; RUMEN

Citation

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.18, no.5, pp.908 - 912

ISSN
1017-7825
URI
http://hdl.handle.net/10203/22624
Appears in Collection
CBE-Journal Papers(저널논문)
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