Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus

Cited 11 time in webofscience Cited 0 time in scopus
  • Hit : 424
  • Download : 0
Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca2+ channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities.
Publisher
CELL PRESS
Issue Date
2017-08
Language
English
Article Type
Article
Keywords

SEPIAPTERIN-REDUCTASE DEFICIENCY; LATERAL GENICULATE-NUCLEUS; DEEP BRAIN-STIMULATION; NIGRA PARS RETICULATA; PARKINSONS-DISEASE; CA2+ CHANNELS; GLOBUS-PALLIDUS; PATHOLOGICAL SYNCHRONIZATION; EFFERENT CONNECTIONS; SUBTHALAMIC NUCLEUS

Citation

NEURON, v.95, no.5, pp.1181 - +

ISSN
0896-6273
DOI
10.1016/j.neuron.2017.08.028
URI
http://hdl.handle.net/10203/226143
Appears in Collection
BiS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 11 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0