Investigation of Control Scans in Pseudo-Continuous Arterial Spin Labeling (pCASL): Strategies for Improving Sensitivity and Reliability of pCASL

Purpose To investigate the performance of control scans in pseudo-continuous ASL (pCASL) and propose strategies for improving sensitivity and reliability of pCASL. Methods The labeling efficiencies of pCASL with conventional control scan and distal control scan were investigated at various radiofrequency (RF) duration/spacing of 0.5/1–2/4 ms, mean slice-selection gradients (GSS) of 1 and 0 mT/m, and total labeling durations of 1.5–3 s, through Bloch equation simulations and in vivo experiments. In addition, the feasibility of three-dimensional (3D) pCASL with the distal control scan and control scan with no RF preparation was demonstrated in a wide brain area, by suppressing the magnetization transfer (MT) effects with high GSS while maintaining the GSS/mean GSS ratio. Results The distal control scan provided pCASL signals approximately 40% higher and more robust to variations in the labeling conditions than those from the conventional control scan. The distal and no RF control scans with high GSS provided uniform pCASL signals in approximately 8-cm-thick imaging region with MT contributions <10% of the perfusion signals. Conclusions pCASL perfusion signals can be enhanced (∼40%) and become more stable by using the distal or no RF control scan, which can be applied in a wide area by increasing GSS while maintaining GSS/mean GSS. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
Publisher
WILEY-BLACKWELL
Issue Date
2017-09
Language
English
Keywords

CEREBRAL-BLOOD-FLOW; ASCENDING/DESCENDING DIRECTIONAL NAVIGATION; STATE FREE PRECESSION; MAGNETIZATION-TRANSFER; HUMAN BRAIN; PERFUSION MEASUREMENTS; IMAGING TECHNIQUES; MR PERFUSION; 7 T; INVERSION

Citation

MAGNETIC RESONANCE IN MEDICINE, v.78, no.3, pp.917 - 929

ISSN
0740-3194
DOI
10.1002/mrm.26474
URI
http://hdl.handle.net/10203/225809
Appears in Collection
BiS-Journal Papers(저널논문)
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