Vasculature-on-a-chip for in vitro disease models

Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculature and its related diseases. A significant evolution has been made to describe the vascularization process so that in vitro recapitulation of vascularization is possible. The current microfluidic systems allow elaborative research on the effects of various cues for vascularization, and furthermore, in vitro technologies have a great potential for being applied to the vascular disease models for studying pathological events and developing drug screening platforms. Here, we review methods of fabrication for microfluidic assays and inducing factors for vascularization. We also discuss applications using engineered vasculature such as in vitro vascular disease models, vasculature in organ-on-chips and drug screening platforms.
Publisher
MDPI
Issue Date
2017-01
Language
English
Citation

Bioengineering, v.4, no.8

ISSN
2306-5354
DOI
10.3390/bioengineering4010008
URI
http://hdl.handle.net/10203/225503
Appears in Collection
ME-Journal Papers(저널논문)
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