Digital micromirror based near-infrared illumination system for plasmonic photothermal neuromodulation

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Light-mediated neuromodulation techniques provide great advantages to investigate neuroscience due to its high spatial and temporal resolution. To generate a spatial pattern of neural activity, it is necessary to develop a system for patterned-light illumination to a specific area. Digital micromirror device (DMD) based patterned illumination system have been used for neuromodulation due to its simple configuration and design flexibility. In this paper, we developed a patterned near-infrared (NIR) illumination system for region specific photothermal manipulation of neural activity using NIR-sensitive plasmonic gold nanorods (GNRs). The proposed system had high power transmission efficiency for delivering power density up to 19 W/mm(2). We used a GNR-coated microelectrode array (MEA) to perform biological experiments using E18 rat hippocampal neurons and showed that it was possible to inhibit neural spiking activity of specific area in neural circuits with the patterned NIR illumination. This patterned NIR illumination system can serve as a promising neuromodulation tool to investigate neuroscience in a wide range of physiological and clinical applications. (C) 2017 Optical Society of America
Publisher
OPTICAL SOC AMER
Issue Date
2017-06
Language
English
Article Type
Article
Keywords

NEURAL ACTIVITY; INTERFACE; NEURONS; LIGHT; PHOTOSTIMULATION; OPTOGENETICS; SENSITIVITY; INHIBITION; RESOLUTION; RETINAS

Citation

BIOMEDICAL OPTICS EXPRESS, v.8, no.6, pp.2866 - 2878

ISSN
2156-7085
DOI
10.1364/BOE.8.002866
URI
http://hdl.handle.net/10203/225164
Appears in Collection
BiS-Journal Papers(저널논문)
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