Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex

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Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2016-07
Language
English
Article Type
Article
Keywords

TEMPORAL-LOBE EPILEPSY; BRAIN-TISSUE RESPONSE; SPIKE-WAVE DISCHARGES; SPRAGUE-DAWLEY RATS; IN-VIVO; MICROELECTRODE ARRAYS; DISSOLUTION CHEMISTRY; CRYSTALLINE SILICON; HIGH-DENSITY; RECORDINGS

Citation

NATURE MATERIALS, v.15, no.7, pp.782 - 782

ISSN
1476-1122
DOI
10.1038/NMAT4624
URI
http://hdl.handle.net/10203/224804
Appears in Collection
BiS-Journal Papers(저널논문)
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