Electrical conductance change of graphene-based devices upon surface modification for detecting botulinum neurotoxin

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We report an electric conductance change in a graphene-based device upon molecular adsorption for detecting botulinum neurotoxin (BoNT) using the antibody-antigen binding strategy. This device consists of a 400-mu m-wide monolayer of graphene between the source and drain electrodes. As-fabricated devices exhibit p-type behaviors. After modifying graphene with linkers and antibodies, BoNT detection was performed by dropping a target solution and measuring the conductance change of the devices. The immobilization of linkers on graphene decreases the electrical conductance as a result of electron transfer from linkers to graphene. However, the conductance change caused by the adsorption of antibodies or BoNTs is ascribed to the top-gating effects of the molecules adsorbed on graphene. The normalized conductance change of the graphene-based device upon antibody-BoNT binding was greater than 5%. (C) 2017 The Japan Society of Applied Physics
Publisher
IOP PUBLISHING LTD
Issue Date
2017-06
Language
English
Article Type
Article
Keywords

ULTRASENSITIVE DETECTION; CLOSTRIDIUM-BOTULINUM; RAMAN-SPECTROSCOPY; ENZYMATIC-ACTIVITY; OXIDE; IMMUNOSENSOR; ADSORPTION; COMPOSITE; BIOSENSOR; DISORDER

Citation

JAPANESE JOURNAL OF APPLIED PHYSICS, v.56, no.6

ISSN
0021-4922
DOI
10.7567/JJAP.56.067001
URI
http://hdl.handle.net/10203/224532
Appears in Collection
MSE-Journal Papers(저널논문)
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