Frequency-Dependent Impedance Analysis for Discriminating Cancer and Normal Cells Using Microchamber Array

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We present an impedance monitoring microchamber array for discriminating normal and cancer cells, the top layer of which is covered to form a stable contact between the cells and the electrodes in each microchamber. Compared with devices in previous works, the present device is capable of maintaining long-term cell-to-electrode contact, simply by loading the cells on the electrodes placed in each microchamber and covering the layer, thereby achieving frequency-dependent impedance analysis without additional apparatus. By comparing the impedance response of two human lung cancer cell lines with a normal lung cell line, we verified that the cancer cells are clearly distinguishable against the normal cells by showing both lower resistance (241 vs 271 k Omega) and capacitance (3.13 vs 7.01 nF) in the frequency range of 200 Hz to 2 MHz. Simplicity of cell loading and the capability for determining characteristics of the cancer cells were demonstrated using the device.
Publisher
MYU
Issue Date
2017-03
Language
English
Article Type
Article; Proceedings Paper
Keywords

MICROFLUIDIC DEVICE; FLOW CYTOMETER; SPECTROSCOPY

Citation

SENSORS AND MATERIALS, v.29, no.3, pp.293 - 301

ISSN
0914-4935
DOI
10.18494/SAM.2017.1405
URI
http://hdl.handle.net/10203/223869
Appears in Collection
BiS-Journal Papers(저널논문)
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