A sticker-type system with hybrid integration of CMOS IC and organic optical sensors is proposed to monitor photoplethysmogram (PPG) signals. To solve problems with the previous solely organic sensor-based works, CMOS IC is implemented in 180 nm technology under 5 V/1.5 V dual power supply. The silver-wire printed planar-fashionable circuit board (P-FCB) is used to connect the CMOS IC with organic sensors. The proposed hybrid system has the five following key features: 1) Power-efficient structure of organic sensor; 2) Integrated analog front-end and digital processor; 3) Degradation compensation scheme; 4) Large parasitic elements optimized design; and 5) Motion artifact rejection scheme. The stickertype PPG monitoring system has mass of only 2g, including the batteries, and consumes only 233 mu W to operate. The PPG signal could be acquired from various body parts (finger, wrist, and neck). The peripheral oxygen saturation level (SpO(2)) extraction results are verified by comparison with a commercial sensor device.