Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's beta-Amyloid Aggregation
Rose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aβ aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4:Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self-assembly under NIR irradiation by generating 1O2. Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ-induced cytotoxicity.
- Publisher
- WILEY-V C H VERLAG GMBH
- Issue Date
- 2017-03
- Language
- English
- Article Type
- Article
- Citation
SMALL, v.13, no.11
- ISSN
- 1613-6810
- Appears in Collection
- MS-Journal Papers(저널논문)
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