Role of schip1 in the regulation of hippo signaling in drosophila = 초파리 쉽원에 의한 히포 신호 전달계의 조절

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Regulation of organ size is essential in animal development, and Hippo (Hpo) signaling is a major conserved mechanism for controlling organ growth. In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki). Expanded (Ex) is a regulator of the Hpo activity, but how they are linked is unknown. Here, we show that Schip1, a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. Ex is required for apical localization of Schip1 in imaginal discs. Schip1 is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1. Taking these findings together, we conclude that Schip1 directly links Ex to Hpo signaling by recruiting Tao-1. This study provides insights into the mechanism of Tao-1 regulation and a potential growth control function for SCHIP1 in mammals.
Advisors
Choi, Kwang-Wookresearcher최광욱researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2016
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2016.8 ,[vi, 82 p. :]

Keywords

Schip1; Tao1; Expanded; Hippo pathway; Organ growth; 쉽원; 타오원; 익스팬디드; 히포신호전달계; 기관 성장

URI
http://hdl.handle.net/10203/222126
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=663105&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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