Correlation between psychiatric phenotype and reactive carbonyl species

Abstract

Parkinson’s disease patients shows mental disorder which is distinctive with other disease symptom caused by neuronal loss. To clarify mental disorder, using DJ-1 gene, one of the major Parkinson’s disease early onset recessive gene, transgenic (TG) or knock-out (KO) animal models, proceeded phenotype screening. Through screening, abnormality of mental parameter, especially anxiety, and hormone level change were de-tected. DJ-1 TG animals shows increase of anxiety and decrease of depression. In addition, based on the fact that DJ-1 function is conjugated with Redox detoxification pathway and defense mechanism, Glyoxalase 1, which is one of the essential enzyme for redox detoxification, gene KO animal model experiments also proceed-ed. Through glyoxalase 1 KO mouse experiments, anxiety parameter shifting was also measured. In addition, the intensity of the symptom was changed depending on the level of in-vivo Reactive Carbonyl Species (RCS). Therefore, there is possibility that Parkinson’s disease psychiatric symptoms are conjugated with Redox mole-cule detoxification. By realizing appropriate regulation of redox system and RCS target neuro-receptor, effec-tive treatment method for Parkinon’s disease psychiatric symptom can be developed.